Bone cancer treatment used for dental fillings

Salvatore Sauro, Professor at University CEU Cardenal Herrera in Spain
Salvatore Sauro, Professor at University CEU Cardenal Herrera in Spain

A new research report has demonstrated how the use of zoledronic acid, in combination with bioactive ion-releasing resin-based restorative materials used as dental adhesive, reduces the degradation of dentin collagen and promotes remineralisation at the resin-dentine interface. The research, led by Salvatore Sauro, Professor at University CEU Cardenal Herrera in Spain, has been published in the Journal of Dental Research.

Zoledronic acid is employed as a treatment for osteoporosis and bone cancer. A bisphosphonate, a class of medication that has previously been associated with poor dental outcomes for some patients, it works by slowing bone breakdown, increasing bone density and decreasing the amount of calcium released from the bones into the blood.

The research performed by Professor Sauro and his team showed that the remineralisation properties of bioactive ion-releasing resin-based materials can be realised when they are employed in combination with biomimetic phosphoproteins’ analogues of dentine mineralisation such as Zoledronic acid. It is well known that resin-hybridized dentin can be affected by the proteolytic action of host-derived matrix metalloproteinases present within the dentine matrix, also in the absence of bacterial enzymes.

However, collagen degradation within incompletely infiltrated hybrid layers may be prevented by biomimetic remineralization of the denuded collagen fibrils within the resin-dentine bonding interface.

The research team which produced this scientific data was leaded by Professor Sauro in collaboration with professor Arzu Tezvergil-Mutluay and Dr. Roda Seseogullari Dirihan from the University of Turku (Finland); Dr. Victor Feitosa, from the Federal University of Ceará (Brazil); Professors Franklin Tay and David Pashley, from Georgia Health Sciences University (United States); Professor Tim Watson from King’s College London Dental Institute at Guy’s Hospital (United Kingdom).

Professor Sauro has recently published two further research papers. The first one accepted in the Journal of Biomaterials Science is about the remineralisation evoked by polycarboxylated microfillers incorporated into resin-based dental adhesives. This was developed in collaboration with researchers from the universities of Wuhan and Shanghai (China), the Vancouver campus of the University of British Columbia (Canada), and the London Dental Institute at Guy’s Hospital (United Kingdom).

The second recent paper, published in the International Journal of Adhesion & Adhesives, focused on the assessment of the adhesion ability of innovative bioactive root canal resin-cements to the root dentin. This research was carried out in collaboration with Professor Arlinda Luzi, at CEU-UCH, and researchers from the Universities of Roma Tor Vergata, Federal University of Ceará (Brazil) and the London Guy’s Hospital (United Kingdom).




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