Researchers develop new material to replace extracted human teeth for dental research

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extracted human teeth for dental research
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Extracted human teeth have long been used in conducting dental research, such as evaluating dental ceramic materials as a crown restoration on tooth. It is an inexpensive and straightforward process that simulates clinical situations. 

However, the collection and use of extracted human teeth is becoming increasingly difficult given the concerns about COVID-19, size-standardisation issues, and also time constraints. All these factors have prompted a need for dentine analog materials that could potentially substitute extracted human teeth in laboratory-based mechanical and fatigue tests.

A research team led by Dr James Tsoi at the University of Hong Kong (HKU), together with colleagues from Wuhan University, China, and Drexel University, US, investigated new elliptical frustums of fiber-reinforced composite materials and compared their properties to that of human dentine.

The materials were tested for their mechanical strength, elastic modulus, indentation hardness and fatigue behaviour. Fatigue behaviour indicates the tenacity of materials under varying loads. The positive results showed that the dentine analog materials analysed can be used as a replacement for human-extracted teeth.

The researchers uniformly fabricated the new dentine analog materials with specific size and shape mimicking natural teeth, adhesively bonded to lithium disilicate crowns, and subjected them to fatigue loading. The restorations showed comparable fatigue failure load and lifetime (durability) to those based on extracted human teeth. This implies that the materials can be well used in lieu of human-extracted teeth.

Finite element analysis, an important method to simulate a physical phenomenon using a numerical technique, also showed promising results. Similar stress levels and distributions between dentine analog materials and extracted human teeth were observed. Notably, it is pivotal that the new materials have similar elastic properties and fatigue performance to human dentine if researchers want to use them for laboratory fatigue tests.

“This study evaluated the mechanical properties and fatigue behaviour of dentine analog materials experimentally, analytically and numerically, and found a material with spectacular size and shape can reliably replace human dentine as the substrate in a ceramic crown fatigue test,” Dr Tsoi said.

“We hope this study can help researchers who are facing the problem of inadequate extracted human teeth and facilitate predictable laboratory research with the aid of dentine analog materials.”

The study is published in Dental Materials

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