Scientists work to bring tissue regeneration to replace root canal treatment

tissue regeneration root canal treatment
Photo: zoranphotographer 123rf

Want to avoid a root canal? In the future, you might be able to opt for tissue regeneration instead. US scientists are testing a novel technology to treat endodontic diseases more effectively. 

The study by a team at ADA Forsyth, Boston—and published in The Journal of Dental Researchdemonstrates the regenerative properties of resolvins, specifically Resolvin E1 (RvE1), when applied to dental pulp. 

Resolvins are part of a greater class of specialised proresolving mediators (SPMs). This class of molecule is naturally produced by the body and is exquisitely effective in the control of excess inflammation associated with disease.

“Pulpitis (inflammation of dental pulp) is a very common oral health disease that can become a serious health condition if not treated properly,” study lead Dr Thomas Van Dyke said.

“Root canal therapy is effective, but it does have some problems since you are removing significant portions of dentin, and the tooth dries out leading to a greater risk of fracture down the road. Our goal is to come up with a method for regenerating the pulp, instead of filling the root canal with inert material.”

Inflammation of this tissue is usually caused by damage to the tooth through injury, cavities or cracking, and the resulting infection can quickly kill the pulp and cause secondary problems if not treated.

The study applied RvE1 to different levels of infected and damaged pulp to explore its regenerative and anti-inflammatory capacities. 

There were two major findings. First, they showed RvE1 is very effective at promoting pulp regeneration when used in direct pulp-capping of vital or living pulp (replicating conditions of reversible pulpitis). They were also able to identify the specific mechanism supporting tissue regeneration.

Second, the scientists found that placing RvE1 on exposed and severely infected and necrotic pulp did not facilitate regeneration. 

However, this treatment did effectively slow down the rate of infection and treat the inflammation, preventing the periapical lesions (abscesses) that typically occur with this type of infection. 

Previous publications have shown that if the infected root canal is cleaned before RvE1 treatment, regeneration of the pulp does occur.

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